You could include debilitating effects.
I expect mortals to get a bit kooky after a few centuries past their due date.
If they don't, I shall be disappointed.
“She'd become a governess. It was one of the few jobs a known lady could do. And she'd taken to it well. She'd sworn that if she did indeed ever find herself dancing on rooftops with chimney sweeps she'd beat herself to death with her own umbrella.”
― Hogfather