The equivalent of "Oh, you make me..."
And it just trails off... Could mean "make me sick", "make me sad", "make me wonder", whatever.
Typically disgust, disappointment or worry.
“…Judge not what a man has done, but judge what he could have done if he was a different bloke altogether. For art thou a leper? And a leper can changeth his spots…” --Rudy Wade, Misfits (Series 4, Episode 8)